USP5 ENHANCES SGTA MEDIATED PROTEIN QUALITY CONTROL

Mislocalised membrane proteins (MLPs) present a risk to the cell due to exposed hydrophobic amino acids which cause MLPs to aggregate.Previous studies identified SGTA as a key component of the machinery that regulates the quality control of MLPs.Overexpression of SGTA promotes deubiqutination of MLPs resulting in their accumulation in cytosolic inc

We present a comprehensive learning design (LD) concept and tool, motivated by the needs identified by higher education (HE) practitioners.The concept and tool aim at implementing contemporary research findings and theory to support balanced LD planning (BDP).The student-centered BDP concept and tool provide innovation to LD planning by strongly fo